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Multi-chamber IV bag has two categories: fluid multi-chamber IV bag and fluid-powder multi-chamber IV bag. It’s defined as the separate storage of different medicine in different sub-chambers by welding during production, storage and transportation. In application, the separate sub-chambers are connected by external forces, and the contents are mixed. Multi-chamber IV bag is mainly used for the contents that are unstable after mixing, and can not guarantee long term storage. This article analyzes the testing of two key factors for multi-chamber IV bags: welding and barrier property. 

1.The Analysis and Testing of Welding Strength

For the welding strength of multi-chamber IV bag, its convenience, safety and protection for isolated contents during storage and transportation must be maintained. Therefore, multi-chamber welding process control is the key procedure in the whole production. Welding is determined by three indexes: temperature, time and pressure. Multi-chamber IV bags, to achieve safe storage and transportation as well as easy clinical operation, can only maintain a mediate welding strength, which is also called heat seal strength. How to control this index successfully is a focus for multi-chamber IV bag manufacturers.

Labthink HST-H3 Heat Seal Tester and XLW (PC) Auto Tensile Tester are the professional testers for multi-chamber IV bag and its indexes. When testing the finished multi-chamber IV bags, a specimen of the welding place is prepared. This specimen can be automatically tested after clamping and pressing the ‘heat seal’ button on XLW (PC). Besides, for the proper welding strength, the manufacturer needs to make researches on temperature, time and pressure. HST-H3 Heat Seal Tester can be applied with the auto tensile tester for the best heat seal temperature, time and pressure indexes.

2.The Analysis and Testing of Barrier

Barrier property is the most important factor affecting the quality of fluid and fluid-powder multi-chamber IV bags. Owing to the low barrier property of the content contact package, a barrier package is needed for prevention of oxygen and moisture permeation. Besides, nitrogen is applied to take place of the air between the inner package and barrier package. Therefore, oxygen transmission as well as nitrogen and moisture transmission should be tested. Labthink VAC-V series of differential pressure gas permeation testers can accomplish relevant testing.

The application of multi-chamber IV bags is the great development of IV bags. As the most strictly required package for medicine, its tensile strength, elongation, heat seal strength, puncture performance of film and closure and seal property all need to be tested. Labthink, as the excellent provider of testing instruments and services, has been providing most excellent and thorough quality control solutions for the global medical industry. Labthink is willing to have more communication and cooperation will pharmaceutical companies and institutions. 

Labthink Instruments Co., Ltd.      

No. 144 Wuyingshan Road, Jinan 250031, China

Tracy Bao  info@labthink.cn

Tel: 0086 531 85061153  fax:0086 531 85812140

 

 

About the Author:

Labthink, the excellent provider of testing instruments and testing services, is devoted to provide most excellent and complete quality control solutions for pharmaceutical, foodstuff, cosmetics, packaging, printing, adhesive, automotive, petrochemistry, environment, biology, new energy, construction, aviation and electronic industries worldwide.

Article Source: ArticlesBase.com - Welding Strength Testing for Multi-chamber IV Bags

This entry was posted on Monday, October 27th, 2008 at 10:20 am and is filed under Uncategorized. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.